Reproduction Abstracts

Ca2+ signaling is crucial for regulation of sperm motility and [Ca2+]i oscillations may underlie ‘switching’ of sperm behaviors in human spermatozoa, which is believed to be important for sperm progression in the female tract. We have investigated the contribution of membrane potential (Vm) and the sperm Ca2+ channel CatSper to [Ca2+]i oscillations induced by progesterone (P4). Manipulation of Vm was p...

Ca2+ signalling is critical for regulation of sperm motility. [Ca2+]i oscillations, which may underlie observed ‘switching’ of sperm behaviors, occur in human spermatozoa stimulated with progesterone. Our work aimed to investigate the potential contribution of changes in membrane potential, leading to cyclical activation of voltage dependent Ca2+-influx pathways, to [Ca2+]i oscillations. Spermatozoa we...